RESEARCH INTERESTS
Chemical biology, Bioorthogonal photocatalysis 
Bioorthogonal chemistry, Photocatalytic chemistry


AWARDS

National Science Fund for Excellent Young Scholars of China 

NG Teng Fong/ Sino Scholarship for Outstanding Youth

Li Ge-Zhao Ning Youth Fund for Life Sciences

 

SELECTED PUBLICATIONS

1. Zhang, X.; Huang, H.; Liu, Y.; Wu, Z.; Wang, F.; Fan, X.*; Chen, P. R.*; Wang, J.*, Optical Control of Protein Functions via Genetically Encoded Photocaged Aspartic Acids. 

J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c03701.

2. Guo, F.; Shan, S.; Gong, X.; Dai, C.; Quan, Z.*; Cheng, X.*; Fan, X.*, Deuteration Degree-Controllable Methylation via a Cascade Assembly Strategy using Methylamine-Water as Methyl Source. 

Chem. Eur. J. 2023, DOI: 10.1002/chem.202301458.

3. Liu, Y.; Ge, Y.; Zeng, R.; Ngai William Shu, C.; Fan, X.*; Chen, P.*, Proximity Chemistry in Living Systems. 

CCS Chem. 2023, 802-813.

4. Fan, X.*; Chen, P.*, Deciphering Life Sciences with “Live” Chemistry—The 2022 Nobel Prize in Chemistry. 

Sci. China Chem. 2023, 66(1), 7-9.

5. Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.; Fan, X.*; Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging. 

Chem 2022, 2179-2191.

6. Ngai, W. S. C.; Yang, S.; Zeng, X.; Liu, Y.; Lin, F.; Wang, X.; Zhang, H.; Fan, X.*; Chen, P.*, Bioorthogonally Activatable Base Editing for On-Demand Pyroptosis. 

J. Am. Chem. Soc. 2022, 144 (12), 5411-5417.

7. Luo, H.; Tang, W.; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.; Fan, X.*; Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells. 

Angew. Chem. Int. Ed. 2022, e202202008. 

8. Huang, Z.; Liu, Z.; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. 

J. Am. Chem. Soc. 2021, 143 (44), 18714-18720. 

9. Wang J; Wang X; Fan X*; Chen P.*, Unleashing the Power of Bond Cleavage Chemistry in Living Systems. 

ACS Cent. Sci. 2021 7 (6), 929-943. 

10. Zhu, J.; Dai, C.; Ma, M.; Yue, Y.; Fan, X.*, Visible light-mediated cross-coupling of electrophiles: synthesis of α-amino amides from isocyanates and ketimines. 

Org. Chem. Front. 2021, 8 (6): 1227-32.

11. Lizandara-Pueyo, C.*; Fan, X.*; Ayats, C.; Pericàs, M. A., Calcium carbonate as heterogeneous support for recyclable organocatalysts. 

J. Catal. 2021, 393, 107-115. 

12. Wang, X.#; Liu, Y.#; Fan, X.#; Wang, J.; Ngai, W. S. C.; Zhang, H.; Li, J.; Zhang, G.; Lin, J.*; Chen, P.* “Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications”, 

J. Am. Chem. Soc. 2019, 141 (43), 17133. 

13. Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis”, 

Org. Lett. 2019, 21 (1), 27-31.

14. Fan, X.*; Gong, X.; Ma, M.; Wang, R.; Walsh, P. J.* “Visible Light-Promoted CO₂ Fixation with Imines to Synthesize Diaryl α-Amino Acids”, 

Nat. Commun. 2018, 9(1), 4936.

Wang, R.; Ma, M.; Gong, X.; Fan, X.*; Walsh, P. J.* “Visible Light-Mediated Umpolung Reactivity of Imines: Ketimine Reductions with Cy₂NMe and Water”, 

Org. Lett. 2018, 2433.

15. Fan, X.; Walsh, P. J.* “Chelation-Controlled Additions to Chiral α- and β-Silyloxy, α-Halo, and β-Vinyl Carbonyl Compounds”, 

Acc. Chem. Res. 2017, 50, 2389.

 

For full list of publications, please see: ‪Xinyuan Fan - ‪Google Scholar

https://scholar.google.com/citations?hl=en&user=W2AGqkQAAAAJ&view_op=list_works&sortby=pubdate