Research Experience
2019-present Dean, College of Chemistry and Molecular Engineering, Peking University
2016-2019 Associate Dean, College of Chemistry and Molecular Engineering, Peking University
2016-present Professor, College of Chemistry and Molecular Engineering, Peking University
2010-2016 Assistant Professor, College of Chemistry and Molecular Engineering, Peking University
2011-present Principal Investigator, Synthetic and Functional Biomolecules Center, Peking University
2011-present Principal Investigator, Peking-Tsinghua Center for Life Sciences
2002 – 2007 Ph. D., College of Chemistry, University of California, Berkeley
1998 – 2002 B. S., Department of Chemistry, Tsinghua University
Research Interests
Integrating chemistry and biology enables probing, understanding, and manipulating biological processes in ways not possible before. Our group focuses on developing chemical tools to elucidate the biological function of glycosylation, with an emphasis on in vivo labeling, visualization, and profiling of glycosylation dynamics. We are particularly interested in exploring the functional roles of glycosylation in metabolic homeostasis and in brain pathophysiology. Much of our research takes a highly interdisciplinary approach to tackle important questions related to human health and disease.
Selected Publications
- Gao, L.; Song, Q.; Liang, H.; Zhu, Y.; Wei, T.; Dong, N.; Xiao, J.; Shao, F.; Chen, X.* “Legionella Effector SetA as A General O-glucosyltransferase for Eukaryotic Proteins” Nat. Chem. Biol. 2019, 15, 213-216.
- Huang, R.; Han, M.; Meng, L.; Chen, X.* “Transcriptome-Wide Discovery of Coding and Noncoding RNA-Binding Proteins” Proc. Natl. Acad. Sci. USA 2018, 115, E3879-E3887.
- Sun, Y.; Hong, S.; Xie, R.; Huang, R.; Lei, R.; Cheng, B.; Sun, D.; Du, Y.; Nycholat, C.; Paulson, J.; Chen, X.* “Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling” J. Am. Chem. Soc. 2018, 140, 3592-3602.
- Qin, W.; Qin, K.; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Wang, C.*; Chen, X.* “Artifical Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling” Angew. Chem. Int. Ed. 2018, 57, 1817-1820.
- Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.*; Chen, X.* “Quantitative Time-Resolved Chemoproteomics Reveals Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis” Proc. Natl. Acad. Sci. USA 2017, 114, E6749-E6758.
- Xie, R.; Dong, L.; Du, Y.; Zhu, Y.; Hua, R.; Zhang, C.; Chen, X.* “In Vivo Metabolic Labeling of Sialoglycans in the Mouse Brain By Using A Liposome-Assisted Bioorthogonal Reporter Strategy” Proc. Natl. Acad. Sci. USA 2016, 113, 5173-5178.
- Lin, L.; Liu, L.; Zhao, B.; Xie, R.; Lin, W.; Li, H.; Li, Y.; Shi, M.; Chen, Y.; Springer, T. A.; Chen, X.* “Carbon Nanotube-Assisted Optical Activation of TGF-β Signaling by Near-Infrared Light” Nat. Nanotech. 2015, 10, 465-471.
- Lin, W.; Du, Y.; Zhu, Y.; Chen, X.* “A Cis-Membrane FRET-Based Method for Protein-specific Imaging of Cell-Surface Glycans” J. Am. Chem. Soc. 2014, 136, 679-687.
- Lin, L.; Tian, X.; Hong, S.; Dai, P.; You, Q.; Wang, R.; Feng, L.; Xie, C.; Tian, Z.*; Chen, X.* “A Bioorthogonal Raman Reporter Strategy for SERS Detection of Glycans on Live Cells” Angew. Chem. Int. Ed. 2013, 52, 7266-7271.
- Xie, R.; Hong, S.; Feng, L.; Rong, J.; Chen, X.* “Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes” J. Am. Chem. Soc. 2012, 134, 9914-9917.
